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KMID : 1101720150190030165
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Physical Activity and Nutrition
2015 Volume.19 No. 3 p.165 ~ p.171
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Resistance exercise training increase activation of AKT-eNOS and Ref-1 expression by FOXO-1 activation in aorta of F344 rats
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Li Meng
Li Wei
Yoon Jin-Hwan
Jeon Byeong-Hwa
Lee Sang-Ki
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Abstract
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Purpose :This study investigated the effects of resistance exercise on the Akt-eNOS, the activation of antioxidant protein and FOXO1 in the aorta of F344 rats.
Methods :Male 7 week-old F344 rats were randomly divided into 2 groups: a climbing group (n = 6) and a sedentary group (n = 6). H&E staining and western blotting were used to analyze the rat aortas and target proteins.
Results :Resistance exercise training did not significantly affect aortic structure. Phosphorylation of AKT and eNOS and expression of MnSOD and Ref-1 were significantly increased while FOXO1 phosphorylation was significantly decreased in the resistance exercise group compared with the sedentary group.
Conclusion :We demonstrate that resistance exercise activates the Akt-eNOS and Ref-1 protein without changes to aortic thickness via FOXO-1 activation in the aorta of F344 rats.
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KEYWORD
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resistance exercise, aorta structure, FOXO1, oxidative stress, MnSOD, Ref-1
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